Nan-O-Style is an interdisciplinary research project, which investigates interactions between nanomaterials (NMs) in consumer products with substances from daily life with a special focus on modern lifestyle products (MLPs) used by adolescents.

In order to perform clinical studies with candidate recombinant allergens the physicochemical properties of these molecules have to be determined according to high-quality standards. As the allergy research group is well-endowed with high-end analytical instruments we aim to improve the existing and develop new bioanalytical tools for allergen standardization.

Understanding the mechanisms of systemic drug hypersensitivity also involves studying drug metabolism and methods of organochemical synthesis and bioconjugation. In the immunological context drugs are usually referred to as haptens eliciting adverse reaction solely upon covalent binding to carrier molecules. Solid diagnosis of drug allergy (skin testing) is thus often eluded by the lack of IgE receptor crosslinking capability of small molecules unless coupled to high molecular weight carriers. We therefore establish methods of preparing and analyzing drug-carrier conjugates also taking into account the possible immunological importance of metabolic drug intermediates.

Research projects

Principle Investigator
2017 – 2019 Nan-O-Style, Nanotechnology ↔ Modern Lifestyle, Sparkling Science, BMWFW, P144200_25
2006 – 2013 Development of bioanalytical tools for standardization of allergen products, Biomay, BIO062004
2010 – 2012 Bioanalysis of allergen extracts and allergoids, Diater, P144250_9
2011 – 2012 Bioanalysis of monomeric allergoids, Lofarma, P144250_9
2006 – 2011 Mechanism of drug-induced hypersensitivity against NSAIDs, FWF P18820-B13
Patterns of exposure and mechanisms of sensitization in allergic asthma caused by tropical mites, FFG 2108908, P144250_6
Managing Th1 and Th2 immune responses for cancer immunotherapy, Boehringer-Ingelheim Fonds, P144250_10
2009 – 2010 Comparative bioanalysis of allergen extracts, Lofarma, P144250_9
Molecule-based diagnosis of allergy and related diseases caused by mites, FFG 823964, P144250_6
2007 – 2009 Biological Standardization Programme – BSP090, Conseil de l’Europe & EDQM,
2006 – 2008 Bioanalysis of allergen extracts and allergoids, Leti, BIO062004

Project participation
2016 – 2019 ICA – Immunity in Cancer and Allergy, International PhD Program, FWF
2016 – 2019 PANDORA – Probing safety of nano-objects by defining immune responses of environmental organisms, EU H2020, 671881,
2014 – 2017 HUMUNITY – Cell-Based Models of Human Mucosal Immunity with Multiple Commercial Applications, 316383,
2013 – 2015 ALRAUNE – Allergieforschung in ruralen, alpinen und urbanen Netzen, BMWFW, OeAD, Sparkling Science
2012 – 2016 Regulation of activation-induced deaminase by lysine modifications, FWF, P24619
2012 – 2015 NanoTOES – Nanotechnology Training of Experts in Safety, EU FP7, 264506,
2012 – 2015 NanoValid – Developing reference methods for nanomaterials, EU FP7, 263147,
2012 – 2015 NanoEIS – Nanotechnology Education for Industry and Society, EU FP7, 319054,