The influence of antigen targeting to sub-cellular compartments on the anti-allergic potential of a DNA vaccine
Esther E. Weinberger, Almedina Isakovic, Sandra Scheiblhofer, Christina Ramsauer, Katrin Reiter, Cornelia Hauser-Kronberger, Josef Thalhamer, Richard Weiss

Abstract:
Recent advances in gene vaccine manipulation offer opportunities for modulation of T helper cell profiles by specific targeting of sub-cellular compartments. In this study we demonstrated, that modified DNA vaccines prevent from allergic sensitization and lung inflammation, prime a Th1-bias and induce regulatory CD4+CD25+ T-cell responses. Targeting the DNA vaccines encoding Bet v 1.0101 to proteasomal or lysosomal degradation was potent in reducing infiltration of bronchoalveolar lavage and rendered the vaccine hypoallergenic, by reducing the availability of native antigen.

The open access article can be found  here

Reviewed by Hans Brandstetter