Tackling Bet v 1 and associated food allergies with a single hybrid protein
Heidi Hofer, Claudia Asam, Michael Hauser, Birgit Naglb, Josef Laimer, Martin Himly, Peter Briza, Christof Ebner, Roland Lang, Thomas Hawranek, Barbara Bohle, Peter Lackner, Fátima Ferreira, Michael Wallner
Abstract:
Birch pollen allergic individuals often also suffer from adverse reactions after the ingestion of apple and hazelnuts. Here, we successfully designed and characterized a novel hybrid protein (MBC4) with reduced allergenicity and retained immunogenicity for the combined treatment of pollen and concomitant food allergies. Furthermore, MBC4 was able to induce IgG antibodies with blocking activity, which are considered a hallmark in allergen immunotherapy.
The open access article can be found  here.

Reviewed by Hans Brandstetter