„Human CD4+CD103+ cutaneous resident memory T cells are found in the circulation of healthy individuals“
Maria M. Klicznik, Peter A. Morawski, Barbara Höllbacher, Suraj R. Varkhande, Samantha J. Motley, Leticia Kuri-Cervantes, Eileen Goodwin, Michael D. Rosenblum, S. Alice Long, Gabriele Brachtl, Thomas Duhen, Michael R. Betts, Daniel J. Campbell, Iris K. Gratz
Abstract: 
Tissue-resident memory T cells (TRM) persist locally in nonlymphoid tissues where they provide frontline defense against recurring insults. TRM at barrier surfaces express the markers CD103 and/or CD69, which function to retain them in epithelial tissues. In humans, neither the long-term migratory behavior of TRM nor their ability to reenter the circulation and potentially migrate to distant tissue sites has been investigated. Using tissue explant cultures, we found that CD4+CD69+CD103+ TRM in human skin can down-regulate CD69 and exit the tissue. In addition, we identified a skin-tropic CD4+CD69−CD103+ population in human lymph and blood that is transcriptionally, functionally, and clonally related to the CD4+CD69+CD103+TRM population in the skin. Using a skin xenograft model, we confirmed that a fraction of the human cutaneous CD4+CD103+ TRM population can reenter circulation and migrate to secondary human skin sites where they reassume a TRM phenotype. Thus, our data challenge current concepts regarding the strict tissue compartmentalization of CD4+ T cell memory in humans.

The open access article can be found  here.
Reviewed by Angela Risch.

CONGRATULATIONS!