Transmission electron microscopy

TransmissionselektronenmikroskopieAnalytical high-performance electron microscope Zeiss EM 910 LaB6 STEM with energy-dispersive X-ray spectrometer, with Koehler illumination beam path, magnification-dependent setting of the condenser diaphragm (AIS) for homogeneous parallel illumination that is gentle on the specimen and includes an STEM detector. A 2K digital camera (Tröndle) is available for documentation.

Methods & expertise on research infrastructure

The transmission electron microscope Zeiss EM 910 enables fine structure analyzes with a resolution of a few nanometers and has many-faceted fields of application, such as

 

  • Structural research in protozoology
  • Vascular research
  • Developmental and tumor biology
  • Muscle biology, including forensic analysis
  • Morphometric / stereological analysis (photo sampling for point counting methods)
  • Various fine structure studies on artropods in taxonomic and ecological context
  • Fine structural analysis of cellular defense processes with formation of the so-called NETs   (neutrophil extracellular traps) for cystic fibrosis (mucoviscidosis), COPD and periodontitis.

Scanning electron microscopy

Rasterelektronenmikroskopie

The FEI ESEM XL30 is a scanning electron microscope with variable pressure control and X-ray microanalysis. It can be used in many ways in biological research. The maximum resolution of the device operated with a tungsten cathode is at 3.5nm. The acceleration voltage can be varied in the range of 0.2 – 30kV.

 

Methods & expertise on research infrastructure

 

  • Vascular and tumor research: Examination of vascular casts (Corrosion Casts) for research   into the growth and development of blood vessels in organs and tissues
  • Analysis of animal and human blood vessel networks with pathological changes on the basis   of microvascular corrosion casts
  • Quantitative three-dimensional evaluation with the 3D morphometry system M3

  • Various fine structure studies on artropods in taxonomic and ecological terms context

A central research area is also the fine-structure analysis of cellular defense processes in inflammatory reactions mediated by neutrophils in chronic human diseases, especially with regard to the formation of the so-called NETs (neutrophil extracellular traps). This affects diseases such as cystic fibrosis (mucoviscidosis), COPD and periodontal disease (also in connection with the triggering of rheumatoid arthritis).