Taylor C, Pretzner B, Zahel T, Herwig C. Architectural and Technological Improvements to Integrated Bioprocess Models towards Real-Time Applications. Bioengineering. 2022;9(10).  https://doi.org/10.3390/bioengineering9100534

Romann P, Kolar J, Tobler D, Herwig C, Bielser JM, Villiger TK. Advancing Raman model calibration for perfusion bioprocesses using spiked harvest libraries. Biotechnol J. 2022:e2200184.  https://doi.org/10.1002/biot.202200184

Oberleitner T, Zahel T, Pretzner B, Herwig C. Holistic Design of Experiments Using an Integrated Process Model. Bioengineering. 2022;9(11).  https://doi.org/10.1016/j.procir.2017.03.369

Maschke RW, Pretzner B, John GT, Herwig C, Eibl D. Improved Time Resolved KPI and Strain Characterization of Multiple Hosts in Shake Flasks Using Advanced Online Analytics and Data Science. Bioengineering (Basel). 2022;9(8).  https://doi.org/10.3390/bioengineering9080339

Kager J, Bartlechner J, Herwig C, Jakubek S. Direct control of recombinant protein production rates in E. coli fed-batch processes by nonlinear feedback linearization. Chemical Engineering Research and Design. 2022;182:290-304.  https://doi.org/10.1016/j.cherd.2022.03.043

Böttinger, K., Huber, C. G., Esser-Skala, W., Segl, M., & Herwig, C. (2022). At-line quantitative profiling of monoclonal antibody products during bioprocessing using HPLC-MS. Analytica Chimica Acta, 2022(1207).  https://doi.org/10.1016/j.aca.2022.339813

Pauk, J.N., Raju Palanisamy, J., Kager, J. et al. Advances in monitoring and control of refolding kinetics combining PAT and modeling. Appl Microbiol Biotechnol 105, 2243–2260 (2021).  https://doi.org/10.1007/s00253-021-11151-y

Kager J, Herwig C. Monte Carlo-Based Error Propagation for a More Reliable Regression Analysis across Specific Rates in Bioprocesses. Bioengineering. 2021;8(11).  https://doi.org/10.3390/bioengineering8110160

Eifert, T., Eisen, K., Maiwald, M. et al. Current and future requirements to industrial analytical infrastructure—part 2: smart sensors. Anal Bioanal Chem 412, 2037–2045 (2020).  https://doi.org/10.1007/s00216-020-02421-1

Daume S, Kofler S, Kager J, Kroll P, Herwig C. Generic Workflow for the Setup of Mechanistic Process Models. Methods Mol Biol. 2020;2095:189-211.  Link to book chapter

Sinner P, Daume S, Herwig C, Kager J. Usage of Digital Twins Along a Typical Process Development Cycle. Advances in Biochemical Engineering/Biotechnology. (2020) ISSN 0724-6145.  Link to book chapter

Paul K, Hartmann T, Posch C, Behrens D, Herwig C. Investigation of cell line specific responses to pH inhomogeneity and consequences for process design. Engineering in Life Sciences. 2020;20(9 – 10):412 – 21.  https://doi.org/10.1002/elsc.202000034

Paul, K., Boettinger, K., Mitic, B. M., Scherfler, G., Posch, C., Behrens, D., Huber, C. G., & Herwig, C. (2020). Development, characterization, and application of a 2-Compartment system to investigate the impact of pH inhomogeneities in large-scale CHO-based processes. Engineering in Life Sciences, 20(8), 368-378.  https://doi.org/10.1002/elsc.202000009

Paul K, Herwig C. Scale‐down simulators for mammalian cell culture as tools to access the impact of inhomogeneities occurring in large‐scale bioreactors. Engineering in Life Sciences. 2020;20(5-6):197-204.  https://doi.org/10.1002/elsc.201900162

Dahlgren GM, Macias KA, Moreira A, Thompson DR, Herwig C, Dream R. Quality and regulatoriy solutions for PAT in continuous manufacturing. Pharmaceutical Engineering. 2020;40(5):52 – 60.  Link to publication

Steinwandter VB, Daniel; Herwig,Christoph;. Data science tools and applications on the way to Pharma 4.0. Drug Discovery Today. 2019;24(9):1795-805.  https://doi.org/10.1016/j.drudis.2019.06.005

Rajamanickam V, Herwig C, Spadiut O. A Generic Workflow for Bioprocess Analytical Data: Screening Alignment Techniques and Analyzing their Effects on Multivariate Modeling. Biochemistry & Analytical Biochemistry. 2019;8(1):1 – 11.  https://doi.org/10.35248/2161-1009.19.8.373

Paul K, Rajamanickam V, Herwig C. Model-based optimization of temperature and pH shift to increase volumetric productivity of a Chinese hamster ovary fed-batch process. J Biosci Bioeng. 2019;128(6):710-5.  https://doi.org/10.1016/j.jbiosc.2019.06.004

Borchert D, Suarez-Zuluaga DA, Sagmeister P, Thomassen YE, Herwig C. Comparison of data science workflows for root cause analysis of bioprocesses. Bioprocess and Biosystems Engineering. 2019:245–56.  https://doi.org/10.1007/s00449-018-2029-6

Neutsch L, Kroll P, Brunner M, Pansy A, Kovar M, Herwig C, et al. Media photo-degradation in pharmaceutical biotechnology – impact of ambient light on media quality, cell physiology, and IgG production in CHO cultures. Journal of Chemical Technology & Biotechnology. 2018;93(8):2141-51.  https://doi.org/10.1002/jctb.5643

Dream R, Herwig C, Pelletier E. Challenges for Implementation. Pharmaceutical Engineering. 2018;38:42-51  Link to publication

Abt; V, Barz; T, Cruz; N, Herwig; C, Kroll; P, Möller; J, et al. Model-based tools for optimal experiments in bioprocess engineering. Current Opinion in Chemical Engineering. 2018;22:244-52  https://doi.org/10.1016/j.coche.2018.11.007