Alex

 Mixed-mobility supported lipid bilayers reveal the modulatory role of immobilized ICAM1 on T cell activation, effector functions and immune synapse organization, Alexander Leithner, Audun Kvalvaag, Tanmay Mitra, Salvatore Valvo, Hannah Dada, Ewoud Compeer, Edward Jenkins, Christoffer Lagerholm, Omer Dushek, Michael L Dustin, bioRxiv, 2025.09. 12.675755, 2025.

 Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency, Alexander Leithner, Oskar Staufer, Tanmay Mitra, Falk Liberta, Salvatore Valvo, Mikhail Kutuzov, Hannah Dada, Jacob Spaeth, Weijie Zhou, Felix Schiele, Sophia Reindl, Herbert Nar, Stefan Hoerer, Maureen Crames, Stephen Comeau, David Young, Sarah Low, Edward Jenkins, Simon J Davis, David Klenerman, Andrew Nixon, Noah Pefaur, David Wyatt, Omer Dushek, Srinath Kasturirangan, Michael L DustinProceedings of the National Academy of Sciences 122 (22), e2425781122, 2025.

 A resource for extracellular vesicles from activated CD4 T cells that relay pro-inflammatory signals, Ashwin K Jainarayanan, Ranjeet Singh Mahla, Jesusa Capera, Mirudula Elanchezhian, Dhanu Gupta, Nithishwer Mouroug Anand, Tom Thomas, Daniel Beckers, Alexander Leithner, Sooraj R Achar, Salvatore Valvo, Mariana Conceição, Elke Kurz, Abhinandan Devaprasad, Sakina Amin, Georgina Berridge, Svenja Hester, Roman Fischer, Pablo F Céspedes, Lynn B Dustin, Matthew JA Wood, Michael L Dustin, bioRxiv, 2024.10. 15.618584, 2024.

 Transmembrane domain–driven PD-1 dimers mediate T cell inhibition, Elliot A Philips, Jia Liu, Audun Kvalvaag, Alexander M Mørch, Anna S Tocheva, Charles Ng, Hong Liang, Ian M Ahearn, Ruimin Pan, Christina C Luo, Alexander Leithner, Zhihua Qin, Yong Zhou, Antonio Garcia-España, Adam Mor, Dan R Littman, Michael L Dustin, Jun Wang, Xiang-Peng Kong, Science immunology 9 (93), eade6256, 2024.

 En-Face Imaging of T Cell-Dendritic Cell Immunological Synapses, Alexander Leithner, Jack Merrin, Michael Sixt, The Immune Synapse: Methods and Protocols, 137-147, 2023.

 Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14, Kathrin Tomasek, Alexander Leithner, Ivana Glatzova, Michael S Lukesch, Calin C Guet, Michael Sixt, Elife 11, e78995, 2022.

 WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues, Florian Gaertner, Patricia Reis-Rodrigues, Ingrid De Vries, Miroslav Hons, Juan Aguilera, Michael Riedl, Alexander Leithner, Saren Tasciyan, Aglaja Kopf, Jack Merrin, Vanessa Zheden, Walter Anton Kaufmann, Robert Hauschild, Michael Sixt, Developmental cell 57 (1), 47-62. e9, 2022.

 A supported lipid bilayer platform to study the impact of bi-specific engager architecture on T cell activation, Alexander Leithner, Srinath Kasturirangan, Michael L Dustin, European Journal of Immunology 51 (S1), 2021.

 Dendritic cell actin dynamics control contact duration and priming efficiency at the immunological synapse, Alexander Leithner, Lukas M Altenburger, Robert Hauschild, Frank P Assen, Klemens Rottner, Theresia EB Stradal, Alba Diz-Muñoz, Jens V Stein, Michael Sixt, Journal of Cell Biology 220 (4), e202006081, 2021.

 Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells, Miroslav Hons, Aglaja Kopf, Robert Hauschild, Alexander Leithner, Florian Gaertner, Jun Abe, Jörg Renkawitz, Jens V Stein, Michael Sixt, Nature immunology 19 (6), 606-616, 2018.

 Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice, Markus Brown, Frank P Assen, Alexander Leithner, Jun Abe, Helga Schachner, Gabriele Asfour, Zsuzsanna Bago-Horvath, JV Stein, Pavel Uhrin, M Sixt, Dontscho Kerjaschki, Science 359 (6382), 1408-1411, 2018.

 Micro-engineered “pillar forests” to study cell migration in complex but controlled 3D environments, Jörg Renkawitz, Anne Reversat, Alex Leithner, Jack Merrin, Michael Sixt, Methods in cell biology 147, 79-91, 2018.

 Fast and efficient genetic engineering of hematopoietic precursor cells for the study of dendritic cell migration, Alexander Leithner, Joerg Renkawitz, Ingrid De Vries, Robert Hauschild, Hans Häcker, Michael K Sixt, European journal of immunology 48 (6), 2018.

 Dendritic cells interpret haptotactic chemokine gradients in a manner governed by signal-to-noise ratio and dependent on GRK6, Jan Schwarz, Veronika Bierbaum, Kari Vaahtomeri, Robert Hauschild, Markus Brown, Ingrid De Vries, Alexander Leithner, Anne Reversat, Jack Merrin, Teresa Tarrant, Tobias Bollenbach, Michael Sixt, Current Biology 27 (9), 1314-1325, 2017.

 Locally triggered release of the chemokine CCL21 promotes dendritic cell transmigration across lymphatic endothelia, Kari Vaahtomeri, Markus Brown, Robert Hauschild, Ingrid De Vries, Alexander Leithner, Matthias Mehling, Walter Anton Kaufmann, Michael Sixt, Cell reports 19 (5), 902-909, 2017.

 Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes, Alexander Leithner, Alexander Eichner, Jan Müller, Anne Reversat, Markus Brown, Jan Schwarz, Jack Merrin, David JJ de Gorter, Florian Schur, Jonathan Bayerl, Ingrid De Vries, Stefan Wieser, Robert Hauschild, Frank PL Lai, Markus Moser, Dontscho Kerjaschki, Klemens Rottner, J Victor Small, Theresia EB Stradal, Michael Sixt, Nature cell biology 18 (11), 1253-1259, 2018.

Daniel

 Analysis of SMAD1/5 target genes in a sea anemone reveals ZSWIM4-6 as a novel BMP signaling modulator, Paul Knabl, Alexandra Schauer, Autumn P Pomreinke, Bob Zimmermann, Katherine W Rogers, Daniel Čapek, Patrick Müller, Grigory Genikhovich, eLife 13:e80803, 2024.

 Uncovering developmental time and tempo using deep learning, Nikan Toulany, Hernán Morales-Navarrete, Daniel Čapek, Jannis Grathwohl, Murat Ünalan, Patrick Müller Nature Methods 20, 2000-2010, 2023.

 EmbryoNet: using deep learning to link embryonic phenotypes to signaling pathways, Daniel Čapek*, Matvey Safroshkin*, Hernán Morales-Navarrete*, Nikan Toulany, Grigory Arutyunov, Anica Kurzbach, Johanna Bihler, Julia Hagauer, Sebastian Kick, Felicity Jones, Ben Jordan, Patrick Müller, 20, 815-823, 2023.

 Single-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model, Timo Kuhn, Amit N Landge, David Mörsdorf, Jonas Coßmann, Johanna Gerstenecker, Daniel Čapek, Patrick Müller, J Christof M Gebhardt, Nature Communications 13(1):6101, 2022.

 Regulation of Nodal signaling propagation by receptor interactions and positive feedback,Hannes Preiß, Anna C Kögler, David Mörsdorf, Daniel Čapek, Gary H Soh, Katherine W Rogers, Hernán Morales-Navarrete, María Almuedo-Castillo, Patrick Müller, eLife 2022 Sep 23;11:e66397, 2022.

 Wie Tiere sich selbst konstruieren, Daniel Čapek, Murat Ünalan, Patrick Müller, Biospektrum, 27, pages 473–477, 2021.

 Positional information and tissue scaling during development and regeneration, Daniel Čapek, Patrick Müller, Development, 146(24), 2019

 Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration, Daniel Čapek, Michael Smutny, Alexandra-Madelaine Tichy, Maurizio Morri, Harald Janovjak, Carl-Philipp Heisenberg, eLife 2019;8:e42093, 2019.

 Interstitial fluid osmolarity modulates the action of differential tissue surface tension in progenitor cell segregation during gastrulation, SF Gabriel Krens, Jim H Veldhuis, Vanessa Barone, Daniel Čapek, Jean-Léon Maître, G Wayne Brodland, Carl-Philipp Heisenberg, Development, 144(10), 1798–1806, 2017.

 Friction forces position the neural anlage, Michael Smutny, Zsuzsa Ákos, Silvia Grigolon, Shayan Shamipour, Verena Ruprecht, Daniel Čapek, Martin Behrndt, Ekaterina Papusheva, Masazumi Tada, Björn Hof, Tamás Vicsek, Guillaume Salbreux, Carl-Philipp Heisenberg, Nature Cell Biology 19 (4), 306–317, 2017.

 Optogenetic control of nodal signaling reveals a temporal pattern of nodal signaling regulating cell fate specification during gastrulation, Keisuke Sako, Saurabh J Pradhan, Vanessa Barone, Alvaro Ingles-Prieto, Patrick Müller, Verena Ruprecht, Daniel Čapek, Sanjeev Galande, Harald Janovjak, Carl-Philipp Heisenberg, Cell Reports 16, 1-12, 2016.

 Thumbs down: a molecular‐morphogenetic approach to avian digit homology, Daniel Čapek, Brian D Metscher, Gerd B Müller, J. Exp. Zool. 322B:1–12, 2014.

* equal contribution