Liste der Publikationen

Stand 01/2026

Publikationen HOREJS-HOECK

PEER-REVIEWED PUBLICATIONS (2016 – 2025)

  1. Ribeiro AR, Eguskiza A, Dang HH, Neuper T, Unger MS, Rodriguez Comas L, Steiner M, Sieberer H, Zaborsky N, Greil R, Vilar I Hernandez M, Jonkheijm P, Fiammengo R, Horejs-Hoeck J. Loading of STING Agonist into Lipid Nanoparticles Boosts Dendritic Cell Activation. ACS Omega. 2025 Nov 21;10(48):58465-58479. doi: 10.1021/acsomega.5c06105. PMID: 41502679; PMCID: PMC12771213.
  2. Kastberger, B.; Sah, A.; Sartori, SB.; Singewald, N.; Liutkevičiūtė, Z.; Risch, A.; Horejs-Höck, J.; Neuhaus, W.; Schartner, J.; Seidl, LF.; Winter, S.; N-Pep-12 Improves Hippocampal Cognitive Function and Increases Neuroplasticity and Neurogenesis Markers. J Diet Suppl. 2025;22(4):525-548. doi: 10.1080/19390211.2025.2499078. Epub 2025 Jun 2. PMID: 40454574
  3. Elmer,D.; Stockmaier, G.; Grund-Gröschke, S.; Strobl, V.; Dang, HH.; Wiederstein, M.; Licha, D.; Strobl, A.; Eglseer, A.; Sternberg, C.;Tezanovic, S.; Gruber, W.; Wolff, F.; Moriggl, R.; Risch, A.; Reischl, R.; Huber, GC.; Krenn, PW.; Fortelny, N.; Horejs-Hoeck, J.; Aberger F. Cooperative Hedgehog/GLI and JAK/STAT signaling drives immunosuppressive tryptophan/kynurenine metabolism via synergistic induction of IDO1 in skin cancer. Cell Communication and Signaling 2025, doi: 10.1186/s12964-025-02046-w
  4. Sieberer, H; Luciano, M; Amend, D; Blöchl, C; Eglseer, A; Steinkellner, A; Rieser, S; Andosch, A; Steiner, P; Hummer, L; Krenn, PW; Dang, HH; Huber, CG; Aberger, F; Neuper, T; Horejs-Hoeck, J. Inhibition of NLRP3 enhances pro-apoptotic effects of FLT3 inhibition in AML, Cell Communication and Signaling 2025, doi: 10.1186/s12964-025-02046-w
  5. Neuper, T.; Frauenlob, T.; Dang, HH.; Krenn, PW.; Posselt, G.; Regl. C.; Fortelny N.; Schäpertöns, V.; Unger, MS.; Üblagger, G.; Neureiter D.; Mühlbacher, I.; Weitzendorfer, M.; Singhartinger , F.; Emmanuel, K.; Huber, GC.; Wessler, S.; Aberger, F.; Horejs-Hoeck J. ADP-heptose attenuates Helicobacter pylori-induced Dendritic Cell activation, Gut Microbes 2024, doi:10.1080/19490976.2024.2402543
  6. Ribeiro, AR.; Neuper, T.; Horejs-Hoeck J. The role of STING-mediated activation of dendritic cells in cancer immunotherapy, International Journal of Nanomedicine, 2024
  7. Luciano, M.; Sieberer, H.; Krenn, PW.; Dang. HH.; Vetter, J.; Neuper, T.; Amend, D.; Blöchl, C.; Weichenberger, CX.; Eglseer, A.; Unger, MS.; Andosch, A.; Steiner, P.; Neureiter, D.; Bauer, R.; Hummer, L.; Tesanovic, S.; Binder, S.; Elmer, DP.; Strandt, H.; Schaller, S.; Strunk, D.; Pleyer, L.; Greil, R.; Winkler, S.; Hartmann, TN.; Schmidt-Arras, D.; Huber,, CG.; Aberger, F.; Horejs-Hoeck J. Targeting NLRP3 inhibits AML progression by inducing PERK/eIF2-mediated apoptosis, Cell Communication and Signaling, 2024, doi: 10.1186/s12964-024-01777-6
  8. Bauer, R; Dang, HH;, Neureiter, D; Unger, MS; Neuper, T; Jensen, M; Taliento, AE; Strandt, H; Gratz, I; Weiss, R; Sales, A; Horejs-Hoeck J. NLRP3 promotes allergic responses to birch pollen extract in a model of intranasal sensitization, Frontiers in Immunology, 2024 doi: 10.3389/fimmu.2024.1393819
  9. Valsalakumari R, Pandya AD, Prasmickaite L, Kvalvaag A, Myrann AG, Åslund AKO, Kjos MS, Fontecha-Cuenca C, Haroon HB, Ribeiro ARS, Horejs-Hoeck J, Moghimi SM, Mørch Ý, Skotland T, Sandvig K, Mælandsmo GM, Iversen TG. Preclinical Efficacy of Cabazitaxel Loaded Poly(2-alkyl cyanoacrylate) Nanoparticle Variants. Int J Nanomedicine, 2024 doi: 10.2147/IJN.S450283
  10. Fux, AC.; Casonato Melo, C.; Schlahs, L.; Burzan, NB.; Felsberger, A.; Gessner, I.; Fauerbach, JA.; Horejs-Hoeck, J.; Droste, M.; Siewert, C. Generation of Endotoxin-Specific Monoclonal Antibodies by Phage and Yeast Display for Capturing Endotoxin. Int J Mol Sci. 2024 doi: 10.3390/ijms25042297.PMID: 38396974
  11. Frauenlob, T.; Neuper, T.; Oswald, AL.; Dang, HH.; Unger, M.; Regl, C.; Schaepertoens, V.; Huber, GC.; Wessler, S.; Horejs-Hoeck, J. Helicobacter pylori induces a novel form of innate immune memory via accumulation of NF-кB proteins. Front Immunol 2023, https://doi.org/10.3389/fimmu.2023.1290833
  12. Urwanisch, L#.; Unger, MS#.; Sieberer, H.; Dang, HH.; Neuper, T.; Regl, C.; Vetter, J.; Schaller, S.; Winkler, SM.; Kerschbamer, E.; Weichenberger, CX.; Krenn, PW.; Luciano, M.; Pleyer, L.; Greil, R.; Huber, CG.; Aberger, F.; Horejs-Hoeck, J. The Class IIA histone deacetylase (HDAC) inhibitor TMP269 downregulates ribosomal proteins and has anti-proliferative and pro-apoptotic effects on AML cells. Cancers 2023, 15(4) 1039; https://doi.org/10.3390/cancers15041039 
  13. Johnson, L.; Aglas, L.; Punz, B.; Dang, HH.; Christ, C.; Pointner, L.; Wenger, M.; Hofstaetter, N.; Hofer, S.; Geppert, M.; Andosch, A.; Ferreira, F.; Horejs-Hoeck, J.; Duschl, A.; Himly, M. Mechanistic insights into silica nanoparticle-allergen interactions on antigen presenting cell function in the context of allergic reactions. Nanoscale. 2023 Feb 2;15(5):2262-2275. doi: 10.1039/d2nr05181h
  14. Luciano, M.; Krenn, P.W.; Horejs-Hoeck, J. The cytokine network in AML. Front Immunol 2022, DOI 10.3389/fimmu.2022.1000996
  15. Barbero, F.; Michelini, S.; Moriones, OH.; Patarroyo, J.; Rosell, JF.; Gusta, M.; Vitali, M.; Martín, L.; Canals, F.; Duschl, A.; Horejs-Hoeck, J.; Mondragón, L.; Bastús, NG.; Puntes, V. Role of Common Cell Culture Media Supplements on Citrate-Stabilized Gold Nanoparticle Protein Corona Formation, Aggregation State, and the Consequent Impact on Cellular Uptake. Bioconjug Chem. 2022 doi: 10.1021/acs.bioconjchem.2c00232
  16. Punz, B.; Johnson, L.; Geppert, M.; Dang, HH.; Horejs-Hoeck, J.; Duschl, A.; Himly, M. Surface Functionalization of Silica Nanoparticles: Strategies to Optimize the Immune-Activating Profile of Carrier Platforms. Pharmaceutics 2022 doi: 10.3390/pharmaceutics14051103
  17. Neuper, T.; Frauenlob, T.; Posselt G.P.; Horejs-Hoeck, J. Beyond the gastric epithelium – the paradox of Helicobacter pylori-induced immune responses. Current Opinion in Immunology 2022, doi: 10.1016/j.coi.2022.102208
  18. Frauenlob, T.; Neuper, T.; Mehinagic, M.; Dang, H. H.; Boraschi, D.; Horejs-Hoeck, J., Helicobacter pylori Infection of Primary Human Monocytes Boosts Subsequent Immune Responses to LPS. Front Immunol 2022, doi: 10.3389/fimmu.2022.847958
  19. Samadi, N.; Koidl, L.; Salzmann, M.; Klems, M.; Komatitsch, N.; Schaffer, D.; Weidmann, E.; Duschl, A.; Horejs-Hoeck, J.; Untersmayr, E. Food Allergen Nitration Enhances Safety and Efficacy of Oral Immunotherapy in Food Allergy. Nutrients 2022, doi.org/10.3390/nu14071373
  20. Neuper, T.; Weiss, R.; Horejs-Hoeck, J. Ripping the Ripoptosome: a novel path for blocking allergic inflammation? Cellular & Molecular Immunology 2022, doi: 10.1038/s41423-021-00815-4m
  21. Blöchl, C.; Holzner, C.; Luciano, M.; Bauer, R.; Horejs-Hoeck, J.; Eckhard, U.; Brandstetter, H.; Huber, C. G., Proteolytic Profiling of Streptococcal Pyrogenic Exotoxin B (SpeB) by Complementary HPLC-MS Approaches. Int J Mol Sci 2021, doi: 10.3390/ijms23010412
  22. Swartzwelter, B.J.; Michelini, S.; Frauenlob, T.; Barbero, F.; Verde, A.; De Luca, A.C.; Puntes, V.; Duschl, A.; Horejs-Hoeck, J.; Italiani, P.; Boraschi, D. Innate memory reprogramming by gold nanoparticles depends on the microbial agents that induce memory. Front Immunol 2021, doi: 10.3389/fimmu.2021.751683
  23. Michelini, S.; Barbero, F.; Prinelli, A.; Steiner, Ph.; Weiss, R.; Verwanger, T.; Andosh, A.; Lütz-Meindl, U.; Puntes, V.F.; Drobne, D.; Duschl, A.; Horejs-Hoeck, J. Gold Nanoparticles (AuNPs) Impair LPS-driven Immune Responses by Promoting a Tolerogenic-like Dendritic Cell Phenotype with Altered Endosomal Structures, Nanoscale, 2021, doi:10.1039/d0nr09153g
  24. Urwanisch, L.; Luciano, M.; Horejs-Hoeck, J. The NLRP3 Inflammasome and Its Role in the Pathogenicity of Leukemia. Int. J. Mol. Sci. 2021, doi.org/10.3390/ijms22031271
  25. Neuper, T., Neureiter. D., Schwarz, H., Sarajlic, M., Bauer, R., Strandt, H., Suchanek, P., Dillon, S.R., Stoecklinger, A., Hammerl, P., Weiss, R., and Horejs-Hoeck, J. Reduced allergen-induced lung inflammation in IL-31 transgenic mice, European Journal of Immunology, 2021, doi.org/10.1002/eji.202048547
  26. Korotchenko, E.; Schießl, V.; Scheiblhofer, S.; Joubert, I.A.; Strandt, H.; Neuper, T.; Sarajlic,M.; Bauer, R.; Geppert, M.; Joedicke, D.; SWildner, S.; Schaller, S.; Winkler, S.; Gadermaier, G.; Horejs-Hoeck, J.; Weiss R.; Laser-facilitated epicutaneous immunotherapy with hypoallergenic beta-glucan neoglycoconjugates suppresses lung inflammation and avoids local side effects in a mouse model of allergic asthma, Allergy, 2021, doi: 10.1111/all.14481
  27. Sarajlic M, Neuper T, Vetter J, Schaller S, Klicznik M, Gratz I, Wessler S, Posselt G, Horejs-Hoeck J. H. pylori modulates DC functions via T4SS/TNFα/p38-dependent SOCS3 expression. Cell Commun Signal, 2020, doi: 10.1186/s12964-020-00655-1
  28. Pinsino, A.; Bastús, N.G.; Busquets-Fité, M.; Canesi, L.; Cesaroni, P.; Drobne,D.; Duschl, A.; Ewart, M.; Gispert, I.; Horejs-Hoeck, J.; Italiani,P.; Kemmerling, B.; Kille, P.; Procházková, P.; Puntes, V.F.; Spurgeon, D.J.; Svendsen, C.; Wilde, C.J.; Boraschi, D.; Probing the immune responses to nanoparticles across environmental species. A perspective of the EU Horizon 2020 project PANDORA. Environ. Sci.: Nano, 2020, 7, 3216-3232, doi.org/10.1039/D0EN00732C
  29. Chichirau BE, Scheidt T, Diechler S, Neuper T, Huber C, Horejs-Hoeck, J., Posselt G, Wessler S. Dissecting the Helicobacter pylori-regulated transcriptome of B cells. Pathog Dis, 2020, Aug 31:ftaa049. doi: 10.1093/femspd/ftaa049
  30. Winter, P.; Stubenvoll, S.; Scheiblhofer, S.; Joubert, I.A.; Strasser, L.; Briganser, C.; Soh, W.T.; Hofer, F.; Kamenik, A.S.; Dietrich, V.; Michelini, S.; Laimer, J.; Lackner, P.; Horejs-Hoeck, J.; Tollinger, M.; Liedl,K.R.; Brandstetter, J.; Huber, C.G.; Weiss, R. „In silico design of Phl p 6 variants with altered folding stability significantly impacts antigen processing, immunogenicity and immune polarization“, Frontiers in Immunology, 2020, doi: 10.3389/fimmu.2020.01824
  31. Klicznik Maria M., Ariane Benedetti, Laura M. Gail, Suraj R. Varkhande, Raimund Holly, Martin Laimer, Angelika Stoecklinger, Andreas Sir, Roland Reitsamer, Theresa Neuper, Jutta Horejs-Hoeck, Michael D. Rosenblum, Daniel J. Campbell, Eva M. Murauer, Iris K. Gratz A novel humanized mouse model to study the function of human cutaneous memory T cells in vivo in human skin. Scientific Reports, 2020, doi: 10.1038/s41598-020-67430-7
  32. Neuper, T.; Frauenlob, T.; Sarajlic, M.; Posselt, G.; Wessler, S.; Horejs-Hoeck, J.; TLR2, TLR4 and TLR10 shape the cytokine and chemokine release of H. pylori-infected human DCs. Int J Mol Sci, 2020 May 29;21(11):E3897. doi: 10.3390/ijms21113897
  33. Joubert, I.A.; Geppert, M.; Johnson, L.; Mills-Goodlet, T.; Michelini, S.; Korotchenko, E.; Duschl, A.; Weiss, R.; Horejs-Höck, J.; Himly, M.; Mechanisms of particles in sensitization, effector function and therapy of allergic disease, Frontiers in Immunology, 2020, Jun 30;11:1334. doi: 10.3389/fimmu.2020.01334
  34. Korotchenko, E.; Moya, R.; Scheiblhofer, S.; Joubert, I.A.; Horejs-Hoeck, J., Hauser, M.; Calzada, D.; Iraola, V.; Carnés, J.; Weiss, R.; Laser-facilitated epicutaneous immunotherapy with depigmented house dust mite extract alleviates allergic responses in a mouse model of allergic lung inflammation. Allergy, 2020 May;75(5):1217-1228. doi: 10.1111/all.14164. Epub 2020 Jan 29. PMID: 31880319
  35. Boraschi, D.; Alijagic, A.; Auguste. M.; Barbero, F.; Ferrari, E.; Hernadi, S.; Mayall, C.; Michelini, S.; Navarro Pacheco, N.I., Prinelli, A.; Swart, E.; Swartzwelter, B.J.; Bastús, N.G.; Canesi, L.; Drobne, D.; Duschl, A.; Ewart, M.; Horejs-Hoeck, J.; Italiani, P.; Kemmerling, B.; Kille, P.; Prochazkova, Puntes, V.F.; Spurgeon, D.V.; Svendsen, C.; Wilde, C.J.; Pinsino, A.; Addressing Nanomaterial Immunosafety by Evaluating Innate Immunity across Living Species. Small. 2020 May 4:e2000598. doi: 10.1002/smll.202000598
  36. Himly, M.; Geppert, M.; Hofer, S.; Hofstätter, N.; Horejs-Höck, J.; Duschl, A.; When Would Immunologists Consider a Nanomaterial to be Safe? Recommendations for Planning Studies on Nanosafety. Small 2020. DOI smll.201907483 
  37. Sarajlic, M.; Neuper, T.; Fohrenbach Quiroz, K. T.; Michelini, S.; Vetter, J.; Schaller, S.; Horejs-Hoeck, J., IL-1β Induces SOCS2 Expression in Human Dendritic Cells. Int J Mol Sci 2019, 20 (23). DOI 10.3390/ijms20235931
  38. Samadi N, Klems M, Heiden D, Bauer R, Kitzmüller C, Weidmann E, Ret D, Ondracek AS, Duschl A, Horejs-Hoeck, J., Untersmayr E. Nitrated food proteins induce a regulatory immune response associated with allergy prevention after oral exposure in a Balb/c mouse food allergy model, Allergy, 2019, Aug 24. doi: 10.1111/all.14030
  39. Aglas L, Gilles S, Bauer R, Huber S, Araujo GR, Mueller G, Scheiblhofer S, Amisi M, Dang HH, Briza P, Bohle B, Horejs-Hoeck, J., Traidl-Hoffmann C, Ferreira F. Context matters: Th2 polarization resulting from pollen composition and not from protein-intrinsic allergenicity. J Allergy Clin Immunol, 2018, 18: 30711-30715. doi: 10.1016/j.jaci.2018.05.004
  40. Michelini S, Sarajlic M, Duschl A, Horejs-Hoeck, J. Dendritic cell activation and feedback inhibition in sterile and non-sterile inflammation. Hum Immunol, 2018, 79:610-615. doi: 10.1016/j.humimm.2018.06.002
  41. Binder S, Luciano M, Horejs-Hoeck, J. The Cytokine Network in Acute Myeloid Leukemia (AML): A Focus on Pro- and Anti-Inflammatory Mediators, Cytokine and Growth Factor reviews, 2018, Oct;43:8-15. doi: 10.1016/j.cytogfr.2018.08.004
  42. Strasser L, Schwarz H, Dang HH, Asam C, Ferreira F, Horejs-Hoeck J, Huber CG. Unbiased Quantitative Proteomics Reveals a Crucial Role of the Allergen Context for the Activation of Human Dendritic Cells. Sci Rep, 2017, 7:16638. doi: 10.1038/s41598-017-16726-2
  43. Li Y, Zhenzhen S, Radauer-Preiml I, Ancuela A, Casals E, Luetz-Meindl U, Cobal M, Zhoumeng L, Jaberi-Douraki M, Italiani P, Horejs-Hoeck J, Himly M, Monteiro-Riviere NA, Duschl A, Puntes V, Boraschi D. Bacterial endotoxin (LPS) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation. Nanotoxicology, 2017, 11:1157-1175. doi: 10.1080/17435390
  44. Neuper T, Ellwanger K, Schwarz H, Kufer TA, Duschl A, Horejs-Hoeck J. NOD1 modulates IL-10 signalling in human dendritic cells. Sci Rep, 2017, 7:1005. doi: 10.1038/s41598-017-00691-x.
  45. Schwarz H, Gornicec J, Neuper T, Parigiani MA, Wallner M, Duschl A, Reich J, Horejs-Hoeck J. Biological Activity of Masked Endotoxin. Sci Rep, 2017, 7: 44750. doi: 10.1038/srep44750
  46. Radauer-Preiml I, Andosch A, Hawranek T, Luetz-Meindl U, Huber C, Wiederstein M, Horejs-Hoeck J, Himly M, Boyles MSP, Duschl A. Human allergic response modulated by interactions of allergens with gold nanoparticles – protein corona characterization and basophil response, Part Fibre Toxicol, 2016, 3: 3. doi: 10.1186/s12989-016-0113-0
  47. Steiner M, Hawranek T, Schneider M, Harrer A, Horejs-Hoeck J, Ferreira F, Himly M. Elevated Toll-like receptor-induced CXCL8 secretion in human blood basophils from allergic donors is independent of Toll-like receptor expression levels. PlosOne, 2016 11: e0149275. doi: 10.1371/journal.pone.0149275

NON-PEER-REVIEWED PUBLICATIONS (2020 – 2024)

  1. Stockmaier, G., Varkhande, S. R., Krenn, P. W., Hieu-Hoa, D., Sharma, A., Elmer, D. P., Steiner, M., Zaborsky, N., Neureiter, D., Greil, R., Horejs-Hoeck, J., Fortelny, N., Gratz, I. K. & Aberger, F. Hedgehog-Hippo pathway interactions promote T cell exclusion from the tumor microenvironment in basal cell carcinoma. bioRxiv 2024 doi:10.1101/2024.07.07.602398.