Tumour Immunology

Cancer is one of the leading causes of death worldwide. Very often patients present at advanced stages of disease with tumor cell dissemination at distant organ sites, a process called metastasis. For many tumor entities an efficient curative therapy is still lacking. Tumour cells are subjected to immunosurveillance. Nevertheless, inflammatory cells and their secreted cytokines can promote tumour growth and metastasis. Our group aims at understanding the molecular mechanisms that underly the skewing of the immune system towards a pro-tumorigenic function. To this end, we not only apply different mouse models, but also use state-of-the art biochemical, cell biological, immunological and bioinformatic methods.

Tumour growth is influenced by cells of the innate and adaptive immunity.



Key contributions

  • Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis. Bolik J, Krause F, Stevanovic M, Gandraß M, Thomsen I, Schacht SS, Rieser E, Müller M, Schumacher N, Fritsch J, Wichert R, Galun E, Bergmann J, Röder C, Schafmayer C, Egberts JH, Becker-Pauly C, Saftig P, Lucius R, Schneider-Brachert W, Barikbin R, Adam D, Voss M, Hitzl W, Krüger A, Strilic B, Sagi I, Walczak H, Rose-John S, Schmidt-Arras D. J Exp Med. 2022 Jan; 219(1): e20201039.  doi:10.1084/jem.20201039
  • The two facets of gp130 signalling in liver tumorigenesis.
    Schmidt-Arras D*, Galun E*, Rose-John S*. Semin Immunopathol. 2021 Aug;43(4):609-624.
     doi: 10.1007/s00281-021-00861-0.
  • Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice.
    Schumacher N, Yan K, Gandraß M, Müller M, Krisp C, Häsler R, Carambia A, Nofer JR, Bernardes JP, Khouja M, Thomsen I,
    Chalupsky K, Bolik J, Hölscher C, Wunderlich T, Herkel J, Rosenstiel P, Schramm C, Schlüter H, Renné T, Mittrücker HW,
    Rose-John S, Schmidt-Arras D. J Hepatol. 2021 Feb;74(2):407-418.
    doi: 10.1016/j.jhep.2020.09.021.
  • Gut microbiota shape ‘inflamm-ageing’ cytokines and account for age-dependent decline in DNA damage repair.
    Guedj A, Volman Y, Geiger-Maor A, Bolik J, Schumacher N, Künzel S, Baines JF, Nevo Y, Elgavish S, Galun E,
    Amsalem H, Schmidt-Arras D, Rachmilewitz J. Gut. 2020 Jun;69(6):1064-1075.
    doi: 10.1136/gutjnl-2019-318491.
  • IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice.
    Bergmann J, Müller M, Baumann N, Reichert M, Heneweer C, Bolik J, Lücke K, Gruber S, Carambia A, Boretius S,
    Leuschner I, Becker T, Rabe B, Herkel J, Wunderlich FT, Mittrücker HW, Rose-John S, Schmidt-Arras D. Hepatology. 2017 Jan;65(1):89-103.
    doi: 10.1002/hep.28874.

Funded by

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