Signal sender


How do members of the ADAM protease family regulate tumorigenesis and metastasis?

ADAM proteases shed ectodomains of cytokines

Signal molecules


How become cytokines selective? And how are they spatio-temporally regulated in the tumour micro-environment?

cytokines have different cellular targets

Signal receiver


How does the immune system influence tumorigenesis? How can we boost anti-tumour immunity?

Innate and adaptive immune cells are involved in anti-tumour immunity.