Growth and survival of tumour cells is subjected to immune surveillance. Pre-cancerous cells are recognized by cells of the innate, as well as cells of the adaptive immune system and subsequently killed. In tumours this system is largely impaired, as anti-tumour immunity is suppressed and mitogenic factors are released by pro-inflammatory immune cells. Cytokines play a key role in this complex interaction of several cell types. We aim to understand how a tumour-permissive immune micro-environment occurs, in particular in tumour metastases.
- Mediators of liver inflammation and carcinogenesis. Herkel J, Schmidt-Arras D. Semin Immunopathol. 2021 Aug;43(4):477-479.
- The two facets of gp130 signalling in liver tumorigenesis. Schmidt-Arras D, Galun E, Rose-John S. Semin Immunopathol. 2021 Aug;43(4):609-624.
- IL-6 trans-signalling is essential for the development of hepatocellular carcinoma in mice. Bergmann, J.; Müller, M..;… and Schmidt-Arras, D. (2017). , Hepatology 65(1):89-103