The family of ADAM (A disintegrin and metalloprotease) proteases has been implicated in a variety of signalling processes. Ectodomain shedding of cytokines like e.g. TNFα, growth-factors like e.g. TGFα and receptors like e.g. Notch have been shown to be mediated by ADAM10 and ADAM17. As such ADAM proteases have been implicated in a number of tumours. However, little is known about the role of ADAM proteases in the tumor stroma and cells of the metastatic niche. We’re investigating how ADAM proteases in the tumour microenvironment regulates primary tumour growth and metastasis.
- Gut microbiota shape ‘inflamm-aging’ cytokines and account for age-dependent decline in DNA damage repair. Guedj A, …, Schmidt-Arras D, Rachmilewitz J. (2020) Gut 69(6):1064-1075.
- ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling. Schmidt, S; …; Schmidt-Arras, D. et al. (2018), J Exp Med 215(4):1205-1225.
- A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis. Müller, M.;… and Schmidt-Arras, D.* (2016). Oncotarget 7(14):17431-41